icm-vls (Molsoft LLC)
90
Structured Review
Molsoft LLC
icm-vls
Icm Vls, supplied by Molsoft LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/icm-vls/icm+vls/pmc11936972-93-20-21
Average 90 stars, based on 1 article reviews
Icm Vls, supplied by Molsoft LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/icm-vls/icm+vls/pmc11936972-93-20-21
Average 90 stars, based on 1 article reviews
icm-vls - by Bioz Stars,
2026-09
90/100 stars
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In Silico:Article Title: Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay Article Snippet: Article Title: Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors Article Snippet: Chromosomal translocations involving anaplastic lymphoma kinase (ALK) are the driving mutations for a range of cancers and ALK is thus considered an attractive therapeutic target.. We synthesized a series of functionalized benzo[4,5]imidazo[1,2-c]pyrimidines and benzo[4,5]imidazo[1,2-a]pyrazines by an aza-Graebe–Ullman reaction, followed by palladium-catalyzed cross-coupling reactions.. A sequential regioselective cross-coupling route is reported for the synthesis of unsymmetrically disubstituted benzo[4,5]imidazo[1,2-a]pyrazines. Article Title: Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors. Article Snippet: Chromosomal translocations involving anaplastic lymphoma kinase (ALK) are the driving mutations for a range of cancers and ALK is thus considered an attractive therapeutic target.. We synthesized a series of functionalized benzo[4,5]imidazo[1,2-c]pyrimidines and benzo[4,5]imidazo[1,2-a]pyrazines by an aza-Graebe–Ullman reaction, followed by palladium-catalyzed cross-coupling reactions.. A sequential regioselective cross-coupling route is reported for the synthesis of unsymmetrically disubstituted benzo[4,5]imidazo[1,2-a]pyrazines. Article Title: Method of treating cancer with modulators of SCFSkp2 Article Snippet: In Silico Assays The in silico protein receptor and ligand preparations, the docking simulations during VLS, and the docking score calculations as well as chemical similarity and substructure searches were carried out with ICM-Pro, ICM-VLS and Article Title: TcSR62, an RNA-binding protein, as a new potential target for anti-trypanocidal agents Article Snippet: We therefore used computational molecular docking to virtually screen the library of U.S. FDA approved drugs against this pocket using Article Title: The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells Article Snippet: In the Article Title: Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core. Article Snippet: A series of simplified ring-opened resorcylic acid lactone (RAL) derivatives were conveniently synthesized to target FLT3 and its mutants either irreversibly or reversibly.. Our design of covalent FLT3 inhibitors is based on cis-enone RALs (e.g., L-783,277) that have a b-resorcylic acid as the core structure.. The designed compounds contain three types of Michael acceptors (acrylamide, vinylsulfonamide and maleimide) as potential covalent traps of a cysteine residue at the binding site of kinases. Article Title: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Article Snippet: In the Software:Article Title: Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay Article Snippet: Article Title: Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors Article Snippet: Chromosomal translocations involving anaplastic lymphoma kinase (ALK) are the driving mutations for a range of cancers and ALK is thus considered an attractive therapeutic target.. We synthesized a series of functionalized benzo[4,5]imidazo[1,2-c]pyrimidines and benzo[4,5]imidazo[1,2-a]pyrazines by an aza-Graebe–Ullman reaction, followed by palladium-catalyzed cross-coupling reactions.. A sequential regioselective cross-coupling route is reported for the synthesis of unsymmetrically disubstituted benzo[4,5]imidazo[1,2-a]pyrazines. Article Title: Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors. Article Snippet: Chromosomal translocations involving anaplastic lymphoma kinase (ALK) are the driving mutations for a range of cancers and ALK is thus considered an attractive therapeutic target.. We synthesized a series of functionalized benzo[4,5]imidazo[1,2-c]pyrimidines and benzo[4,5]imidazo[1,2-a]pyrazines by an aza-Graebe–Ullman reaction, followed by palladium-catalyzed cross-coupling reactions.. A sequential regioselective cross-coupling route is reported for the synthesis of unsymmetrically disubstituted benzo[4,5]imidazo[1,2-a]pyrazines. Article Title: Method of treating cancer with modulators of SCFSkp2 Article Snippet: In Silico Assays The in silico protein receptor and ligand preparations, the docking simulations during VLS, and the docking score calculations as well as chemical similarity and substructure searches were carried out with ICM-Pro, ICM-VLS and Article Title: TcSR62, an RNA-binding protein, as a new potential target for anti-trypanocidal agents Article Snippet: We therefore used computational molecular docking to virtually screen the library of U.S. FDA approved drugs against this pocket using Article Title: The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells Article Snippet: In the Article Title: Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core. Article Snippet: A series of simplified ring-opened resorcylic acid lactone (RAL) derivatives were conveniently synthesized to target FLT3 and its mutants either irreversibly or reversibly.. Our design of covalent FLT3 inhibitors is based on cis-enone RALs (e.g., L-783,277) that have a b-resorcylic acid as the core structure.. The designed compounds contain three types of Michael acceptors (acrylamide, vinylsulfonamide and maleimide) as potential covalent traps of a cysteine residue at the binding site of kinases. Article Title: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Article Snippet: In the Binding Assay:Article Title: Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay Article Snippet: Article Title: Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors Article Snippet: Chromosomal translocations involving anaplastic lymphoma kinase (ALK) are the driving mutations for a range of cancers and ALK is thus considered an attractive therapeutic target.. We synthesized a series of functionalized benzo[4,5]imidazo[1,2-c]pyrimidines and benzo[4,5]imidazo[1,2-a]pyrazines by an aza-Graebe–Ullman reaction, followed by palladium-catalyzed cross-coupling reactions.. A sequential regioselective cross-coupling route is reported for the synthesis of unsymmetrically disubstituted benzo[4,5]imidazo[1,2-a]pyrazines. Article Title: Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors. Article Snippet: Chromosomal translocations involving anaplastic lymphoma kinase (ALK) are the driving mutations for a range of cancers and ALK is thus considered an attractive therapeutic target.. We synthesized a series of functionalized benzo[4,5]imidazo[1,2-c]pyrimidines and benzo[4,5]imidazo[1,2-a]pyrazines by an aza-Graebe–Ullman reaction, followed by palladium-catalyzed cross-coupling reactions.. A sequential regioselective cross-coupling route is reported for the synthesis of unsymmetrically disubstituted benzo[4,5]imidazo[1,2-a]pyrazines. Article Title: Method of treating cancer with modulators of SCFSkp2 Article Snippet: In Silico Assays The in silico protein receptor and ligand preparations, the docking simulations during VLS, and the docking score calculations as well as chemical similarity and substructure searches were carried out with ICM-Pro, ICM-VLS and Article Title: TcSR62, an RNA-binding protein, as a new potential target for anti-trypanocidal agents Article Snippet: We therefore used computational molecular docking to virtually screen the library of U.S. FDA approved drugs against this pocket using Article Title: The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells Article Snippet: In the Article Title: Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core. Article Snippet: A series of simplified ring-opened resorcylic acid lactone (RAL) derivatives were conveniently synthesized to target FLT3 and its mutants either irreversibly or reversibly.. Our design of covalent FLT3 inhibitors is based on cis-enone RALs (e.g., L-783,277) that have a b-resorcylic acid as the core structure.. The designed compounds contain three types of Michael acceptors (acrylamide, vinylsulfonamide and maleimide) as potential covalent traps of a cysteine residue at the binding site of kinases. Article Title: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. Article Snippet: In the |